Today we’d like to introduce you to Jillian Simon.
Hi Jillian, we’d love for you to start by introducing yourself.
I’ve always been fascinated by how people age. Not just how long they live, but how they live. Growing up, I spent a lot of time listening to the women in my family talk around the table at the end of the day. They were strong and hilarious, but underneath there was a lot of exhaustion, pain, and “this is just what happens when you get older.” I didn’t have the language for hormones or metabolism yet, but I could feel how much they were carrying with very little support.
That curiosity eventually became my career. I trained as a nurse practitioner and spent years in traditional healthcare. I loved my patients, but I kept running into the same wall: people, especially women, were being told they were “fine” on paper while clearly not feeling fine in real life. Most of what was being offered were quick fixes instead of true, root-cause care.
Endoura Effect was born out of that gap. I wanted a clinician-guided clinic in Minnesota that treats aging as something we can engage with intelligently, not just endure. We look at hormones, metabolism, peptides, nervous system health, and lifestyle as one connected ecosystem, and we use advanced labs and data to personalize care instead of relying on one-size-fits-all protocols.
As we built Endoura Effect, I realized the model itself needed better infrastructure, which led me to found TiTrio, a health-tech platform that helps micro-clinics automate operations and scale this style of care without losing the human piece. Currently, I sit at the intersection of clinician, founder, and woman in tech, building the clinic I wish existed for the women in my family and the tools I wish existed for clinicians. At the heart of it, the vision is simple: help more people move through every decade of life feeling more resourced, more informed, and more at home in their own bodies.
Alright, so let’s dig a little deeper into the story – has it been an easy path overall and if not, what were the challenges you’ve had to overcome?
Getting here hasn’t been a straight line. It’s meant leaving the security of traditional roles, building a business model to stay patient-centered, learning the world of entrepreneurship, and designing systems that actually support this kind of care instead of fighting it. There have been a lot of late nights, hard lessons, and moments of starting over. But every time a patient says, “I finally feel like myself again,” it confirms exactly why this work exists.
Those early challenges ultimately pushed us to grow, innovate, and stay true to who we are.
Great, so let’s talk business. Can you tell our readers more about what you do and what you think sets you apart from others?
Endoura Effect was born out of a pattern I couldn’t ignore: people being told they were “fine” on paper while clearly not feeling fine in their actual lives. I’m wired for pattern recognition, and what I kept seeing was what I often refer to as “McDonald’s medicine” – quick visits, checkbox care, and the same menu of treatments for everyone. Endoura was built as the opposite: slower, more thoughtful, and truly individualized.
Endoura Effect is a clinician-guided longevity and hormone optimization clinic based here in Minnesota, and our focus is what I call intelligent aging. A lot of our patients are women in perimenopause or menopause, men who want to protect their edge as they get older, and people who quietly know something has shifted in their energy, mood, sleep, or weight but haven’t been taken seriously yet.
On a practical level, we work with hormones, metabolism and weight (including GLP-1 medications when they’re a good fit), peptide and longevity therapies, thyroid and gut health, and we pay close attention to the nervous system. We don’t see those as separate topics; they’re all part of one story about how your body is adapting to stress, aging, and your environment. We use advanced labs and data, but the goal is simple: help you feel clearer, stronger, and more at home in your own body.
What sets Endoura apart is the way we work with people. Visits are longer. We actually talk. We look at your labs and your lived experience. You’re not rushed through a protocol or told “this is normal for your age” and sent on your way. We’re a cash-pay clinic by design so we can keep the care patient-centered; many people use HSA/FSA funds, and we’re transparent about pricing before anything starts.
Brand-wise, I’m proud that we don’t sell perfection or “anti-aging.” We are not interested in shaming anyone into care. We are interested in helping people understand what their body is trying to say and giving them tools to respond. The Endoura brand is modern and warm, but it’s also very direct. We talk about things like weight gain, brain fog, low libido, burnout, and midlife identity shifts without pretending they’re superficial or vain.
If there’s one thing we want readers to know, it’s this: if you’ve been told everything looks normal but you feel anything but normal, you’re not crazy and you’re not alone. That’s exactly the gap Endoura Effect exists to fill.
Endoura Effect, is leading a new era of precision wellness, where data, genetics, and human connection converge- it isn’t just about data, it’s about translating that data into meaning, and that meaning into healing. Endoura Effect exists to make that translation possible.
We’d love to hear about any fond memories you have from when you were growing up?
One of my favorite childhood memories is sitting at my grandmother’s kitchen table, usually playing phase10, listening to the women talk long after the “kids” were supposed to be in bed. I didn’t know anything about hormones, metabolism, or perimenopause yet, but I could feel how much they were carrying in their bodies and how little support they were getting as they aged.
Those late-night conversations stayed with me. They’re a big part of why I became a clinician and why I built Endoura Effect. I wanted a place where people don’t just wait for their health to fall apart and then react, but instead have access to intelligent, proactive care that helps them age with strength, clarity, and vitality. Our work is about hormones, yes, but also metabolism, longevity, nervous system health, and the bigger question of: How do we want to feel in the next decade of our lives, not just this week?
Contact Info:
- Website: https://www.endouraeffect.com
- Instagram: https://www.instagram.com/endouraeffect
- Facebook: https://www.facebook.com/EndouraEffect
- Youtube: https://www.youtube.com/@EndouraEffect
